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Hierarchically porous bioceramics based on geopolymer-hydroxyapatite composite as a novel biomaterial: Structure, mechanical properties and biocompatibility evaluation
| Citace: |
DE ANDRADE, R. CASAGRANDE PAIM, T. BERTACO, I. NAASANI, LS. BUCHNER, S. KOVÁŘÍK, T. HÁJEK, J. WINK, MR. Hierarchically porous bioceramics based on geopolymer-hydroxyapatite composite as a novel biomaterial: Structure, mechanical properties and biocompatibility evaluation. Applied Materials Today, 2023, roč. 33, č. AUG 2023, s. nestránkováno. ISSN: 2352-9407
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| Druh: | ČLÁNEK |
| Jazyk publikace: | eng |
| Anglický název: | Hierarchically porous bioceramics based on geopolymer-hydroxyapatite composite as a novel biomaterial: Structure, mechanical properties and biocompatibility evaluation |
| Rok vydání: | 2023 |
| Autoři: | Rafaela de Andrade , Thaís Casagrande Paim , Isadora Bertaco , Liliana Sous Naasani , Silvio Buchner , Ing. Tomáš Kovářík Ph.D. , Bc. Jiří Hájek , Márcia Rosângela Wink |
| Abstrakt CZ: | V této studii byla technikou replik syntetizována porézní biokeramika s otevřenými buňkami na bázi geopolymerů. Složení se skládalo ze směsi metakaolinu (MK) a hydroxyapatitu (HA), které jsou v kombinaci vhodné pro použití v kostním tkáňovém inženýrství. Metakaolin je levný přírodní hlinitokřemičitan, který je známý pro své mechanické vlastnosti, zatímco hydroxyapatit vyniká svou biokompatibilitou, díky chemické struktuře podobné kostní matrix. Syntetizovaný geopolymer-hydroxyapatit (GMK-HA) byl po tepelném zpracování (HT) podroben tepelné úpravě (značen jako GMK-HA-HT). V práci byly vyhodnoceny chemicko-fyzikální vlastnosti keramických matric tj. chemické složení, porosita, morfologie, fázové složení, včetně buněčné interakce (ADSCs) s povrchem tohoto anorganického kompozitu. |
| Abstrakt EN: | In this study, open-cell porous bioceramics based on geopolymers were synthesized by the replica technique. The composition consisted of a mixture of metakaolin (MK) and hydroxyapatite (HA) that combined are suitable for application in bone tissue engineering. Metakaolin is a cheap natural aluminosilicate known for its mechanical properties, while hydroxyapatite stands out for its biocompatibility due to the chemical structure similar to the bone matrix. After undergoing heat treatment (HT), the geopolymer-hydroxyapatite (GMK-HA) synthesized materials, referred to as GMK-HA-HT, presented pores in the range from 1 to 5 mm. In the compressive strength tests, they exhibited values between 1.18 and 2.9 MPa. These ranges of values signify a proper balance between mechanical strength and porosity. X-ray diffraction analysis showed phosphate and/or calcium crystalline phases in all heat-treated samples, indicating HA?s successful incorporation in the geopolymer structure. In vitro tests using human adipose-derived mesenchymal stem cells (ADSCs) were conducted to evaluate the biocompatibility of the synthesized materials. The extracts obtained from the GMK-HA-HT were found to be non-cytotoxic. ADSCs in contact with extracts have no morphological changes and when cultured on the GMK-HA-HT surface, the cells interacted with the scaffold and formed a monolayer. Here, for the first time, we provide insights into this new class of materials as a promising biomaterial candidate which could be associated with ADSCs to promote bone healing. |
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